F11R and infection: Fig 8H shows that when IHGE cells overexpressing JAM1 were infected with P. gingivalis for 1 h, the remaining JAM1 proteins were present at almost the same level as in non-infected IHGE cells, suggesting that overexpression of JAM1 effectively compensated degradation. Indeed, 1 h after infection, the levels of JAM1 in the lower layer were increased when the cells in the upper layer overexpressed JAM1 (Fig 8I).