The localization of JAM1 in IHGE cells prompted us to examine the degradation of immature and mature JAM1 by P. gingivalis. Myc-mCherry–tagged HA-inserted JAM1 was ectopically expressed in IHGE cells, and the kinetics of Myc- and HA-tagged JAM1 were examined after infection with P. gingivalis (Fig 4A). The gene discussed is F11R; the disease is infection.