However, the combined detrimental effects with APOE e4 genotype and high blood pressure was attenuated among e4 carriers who had their hypertension treated, consistent with results from Qui et al. (2003), who reported that the joint effect of APOE e4 genotype and high systolic pressure was diminished among participants who used antihypertensive drugs [12]. The gene discussed is APOE; the disease is Hypertension.