APOE and hypertensive disorder: Compared with the referent group without hypertension and e3/e3 carriers, women with untreated hypertension who had at least one APOE e4 allele scored 1.02 units lower on the TICS (95% CI: -1.29, -0.76; p<0.0001), which is cognitively equivalent to the effect of aging by 5.1 years (-0.20 units per 1 year of aging, 95% CI: -0.22, -0.18; p<0.0001) (Fig 2a).