These observations are in line with several previous studies on individual MLH1 variants (Cravo et al., 2002; Kosinski et al., 2010; Perera and Bapat, 2008; Raevaara et al., 2005) including a thorough analysis by Takahashi et al. (2007), and also agree with tissue staining of tumor cells from patients with germline MLH1 mutations (Hampel et al., 2008; de Jong et al., 2004). The gene discussed is MLH1; the disease is neoplasm.