CRB1 and retinal degeneration: Mutations in human CRB1 induce retinal degeneration (Richard et al., 2006b; Bulgakova and Knust, 2009), similar as mutations in Drosophila crb (Johnson et al., 2002; Pocha et al., 2011a; Pellikka et al., 2002; Izaddoost et al., 2002; Chartier et al., 2012; Spannl et al., 2017) or overexpression of dominant negative versions (Pellikka and Tepass, 2017).