Furthermore, disruption of MyoVB, Rab8a, Rab11a, Syntaxin three and Syntaxin binding protein 2, all lead to defects similar to the ones observed in MVID enterocytes (Sidhaye et al., 2016; Feng et al., 2017; Vogel et al., 2017; Schneeberger et al., 2015; Mosa et al., 2018). This evidence concerns the gene RAB8A and microvillus inclusion disease.