Consistently, the PTEN signaling pathway, which is an endogenous inhibiting signal of phagocytosis,35 was predicted to be strongly inhibited (z‐score <−2, P < .01; Figure 2A) in brain macrophages after cerebral ischemia, further supporting the overall enhanced phagocytic capacity of brain macrophages. This evidence concerns the gene PTEN and Cerebral ischemia.