AKT1 and gastric ulcer: 2018). And it is regulated by multiple upstream proteins, such as PI3K (Luo et al. 2014) and PTEN (Lee et al. 2013). Previous literature has reported that the IGF-1/PTEN/Akt/FoxO signalling pathway plays a certain role in the protection against ulceration through the regulation of cellular apoptosis as observed in the development and healing of rat gastric ulcers (Huang et al. 2012), which strengthen our research on this signal pathway.