As mediators of intercellular communication, exosomes play a critical role in establishing the tumor microenvironment.12 in vitro studies have confirmed that exosomes obtained from lung cancer cells may activate NF‐κB‐TLR, JAK‐STAT, Fas/FasL, PI3K/AKT/GSK3β,13 and other signaling pathways.14, 15 We confirmed, through examination of clinical samples, that exosomes obtained from patients with lung cancer carry E‐cadherin. This evidence concerns the gene AKT1 and neoplasm.