Malignant fibrous histiocytoma amplified sequence 1 (MFHAS1), a member of the C-terminal of Ras of complex proteins (ROCO) protein family [16,17], was initially found in malignant fibrous histiocytoma, it could regulate TLR-dependent signaling pathway, which was closely related to the occurrence and development of tumors [18]. Here, MFHAS1 is linked to histiocytoma.