BRAF and neoplasm: A phase III randomized trial (COMBI-AD) comparing dabrafenib plus trametinib with placebo for patients with stage III BRAF mutant melanoma, except for <1 mm of tumor burdens in the SLN, showed improved RFS in the dabrafenib/trametinib group after a median follow-up of 44 months in the dabrafenib/trametinib group and 42 months in the placebo group (24).