Immunostaining of human colonic samples showed that REG1A correlated with TP53 (p53) overexpression in the development of UC-associated neoplasia (Tanaka et al., 2011) while a considerable number of p53-overexpressing high-grade dysplasias and invasive carcinomas were negative for REG1A. The gene discussed is REG1A; the disease is invasive carcinoma.