REG1A and diabetes mellitus: Indeed, various Reg proteins are linked to diabetes (Gurr et al., 2002; Martin et al., 2008; Astorri et al., 2010; Bacon et al., 2012; Cox et al., 2015; Yang et al., 2015), pancreatitis (Michael et al., 2000; Bluth et al., 2008; LaFonte et al., 2013) and pancreatic cancer (Grutzmann et al., 2003; Takehara et al., 2006; Legoffic et al., 2009; Park et al., 2011; Radon et al., 2015; Li et al., 2016b).