Our previous studies have characterized the promoters driving transcription of BARTs and show that this abundant transcription is driven by C/EBP and aberrant NF-κB signaling, and that BART miRNAs in turn modulate NF-κB activation through LMP1 in an auto-regulatory loop in NPC cells (9, 10). This evidence concerns the gene CEBPA and nasopharyngeal carcinoma.