However, ceritinib was approved by CFDA for ALK-positive NSCLC patients who had progressed on crizotinib or could not tolerant the toxicity of crizotinib on 31st May, 2018; and alectinib was approved by CFDA for ALK-positive NSCLC patients on 12th August, 2018. The gene discussed is ALK; the disease is non-small cell lung carcinoma.