Johung et al. (25) found that “absence of extracranial metastases, Karnofsky performance score ≥90, and no history of TKIs before development of brain metastases were associated with improved survival in ALK positive patients with brain metastasis.” In Xu's study (26), “long PFS with crizotinib (≥10.4 months), intracranial progression, and use of next-generation ALK inhibitors might be favorable predictors for OS in advanced ALK-positive NSCLC patients.” The gene discussed is ALK; the disease is non-small cell lung carcinoma.