FOXA2 and metastatic malignant neoplasm in the lymph nodes: Finally, HNF3β expression (HR = 0.606, 95% CI, 0.392–0.937, P = 0.024), lymph node metastasis (HR = 0.171, 95% CI, 0.032–0.899, P = 0.037), and UICC clinical stage (HR = 9.935, 95% CI, 2.214–44.574, P = 0.003) were independent prognostic factors for PFS in colon cancer patients (Table 3).