APP and Alzheimer disease: Presenilins are evolutionarily conserved proteins, which serve as the γ-secretase multi-protein complex catalytic subunit and act as novel regulators of cellular zinc and copper uptake [5]. The γ- secretase multi-protein complex is responsible for cleaving AβPP; however, mutations resulting in overexpression of presenilin, particularly in the genes encoding presenilins PS1 and PS2, are crucial indicators of the majority of AD cases [5].