Initial Rx with prednisone 40 mg OD increased platelet count to 135000 cells/mL in 3 months. The patient then developed refractory thrombocytopenia in next 5 years. After HP test came positive, the patient was treated with triple therapy (Clarithromycin 500 mg BD Amoxicillin 1000 mg BD Lansoprazole 30 mg BD) for 14 days. This evidence concerns the gene HP and Thrombocytopenia.