Every patient with unexplained thrombocytopenia should undergo HP testing, including non-invasive tests, such as urea breath test, anti-HP antibodies, and stool antigen test, followed by invasive tests such as endoscopy and biopsy. HP eradication therapy with triple therapy (amoxicillin, clarithromycin, and PPI) should be tried in every ITP case where HP testing is positive or patients aren’t responding to conventional therapies. This evidence concerns the gene HP and autoimmune thrombocytopenic purpura.