In this study, we identified 10 significantly overexpressed hub genes (MCM4, CKS2, ZWINT, HMGB2, MCM7, KPNA2, E2F1, H2AFX, KIF23, and EZH2) and four lncRNAs (FAM182B, SNHG1, SNHG3, and SNHG6) and found them to be negatively correlated with HCC prognosis. The gene discussed is H2AX; the disease is hepatocellular carcinoma.