KEGG analysis demonstrated that DEGs were particularly enriched in the cell cycle, microRNAs involved in cancer, central carbon metabolism in cancer, pentose phosphate pathway, PI3K-Akt signaling pathway, fluid shear stress and atherosclerosis, colorectal cancer, non-alcoholic fatty liver disease, small cell lung cancer, and cellular senescence (Fig. 3D). Here, AKT1 is linked to atherosclerosis.