We performed survival analysis on the hub genes and DElncRNAs and found that 10 overexpressed hub genes (MCM4, MCM7, ZWINT, KPNA2, CKS2, KIF23, E2F1, HMGB2, EZH2, and H2AFX) were significantly related to poorer prognosis with worse survival times in HCC patients. Here, HMGB2 is linked to hepatocellular carcinoma.