ALCAM and neoplasm: Further work, using a large scale tissue microarray format, noted ALCAM expression predominantly at the membrane with any cytoplasmic staining correlating with strong membranous expression and similarly associated high membranous ALCAM immunostaining to correlate with favorable tumor characteristics such as T stage, nodal status and preoperative PSA, with high ALCAM expression also linked to reduced risk of biochemical recurrence [22].