Induction of selective tumor cell death was also studied in vivo in immunodeficient mice growing orthotopic tongue tumors, showing that both 7D12 and 7D12-9G8 anti-EGFR-IRDye700DX conjugates allowed selective OI of the tumors, and that in particular the 7D12 anti-EGFR-IRDye700DX conjugate consistently induced near-complete tumor eradication with little to no toxicity in healthy tissues 139. Here, EGFR is linked to tongue neoplasm.