CXCL10 and breast neoplasm: In another example, hydroxyurea and cisplatin were shown to cause DNA damage in BRCA1-deficient breast tumors, which upregulated the secretion of C-X-C motif chemokine 10 (CXCL10) and chemokine (C-C motif) ligand 5 (CCL5) chemokine in a DNA damage-associated manner involving a STING-TBK1-IRF3 signaling pathway 96.