To expand on this observation, the expression of Arpc2 and Arpc3, the subunits of Arp2/3, in the gastric cancer cells which had been treated with BBI608 or not were examined and it was found that BBI608 could downregulate the protein level of Arpc2 and Arpc3 upregulated by HOXA11. The gene discussed is ARPC3; the disease is gastric cancer.