Whilst, HOXA11-Stat3 regulated migration and invasion in gastric cancer cell relied on the Arp2/3 complex dependent signaling axis, further investigation demonstrated activation of apoptosis signaling pathways in NCI-N87-HOXA11 and SGC-7901-HOXA11 cells treated with Stat3 inhibition as evidenced by downregulation of the anti-apoptosis protein Bcl2. Here, STAT3 is linked to gastric cancer.