HOXA11 and gastric cancer: We evaluated the methylation level and expression of HOXA11 in TCGA gastric cancer database using MethHC (http://methhc.mbc.nctu.edu.tw/php/index.php) 31, the results revealed that hypermethylation of promoter decrease the HOXA11 expression (R=-0.529, P<0.0001; Figure 8D), furthermore, methylation data of the only two paired gastric cancer tissues and matched peritumor normal tissues was consistent with BSP result very well (Figure 8E).