The current state of the art and latest findings shown that expression of HOXA11 is epigenetically repressed by DNA methylation in human gastric cancer 37, and our prior studies have confirmed that knockdown of MTA2 (metastasis associated 1 family, member 2) could decrease the expression of HOXA11 in gastric cancer cells (Figure S1A) 38, there are still gaps in our understanding of the complex processes by which HOXA11 regulates peritoneal metastasis. This evidence concerns the gene HOXA11 and gastric cancer.