Apoptosis or anoikis, tested in vitro by culturing cells in attachment or suspension respectively, were reduced in HOXA11 high-expressed gastric cancer cells compared to the control ones (Apoptosis: NCI-N87: P<0.01, SGC-7901: P<0.05; anoikis: NCI-N87: P<0.05, SGC-7901: P<0.05), correspondingly, Apoptosis or anoikis were increased in MGC-803 cells which HOXA11 was knocked down (Apoptosis: #1: P<0.001 and #2: P<0.001; anoikis: #1: P<0.01 and #2: P<0.05), above results indicated that HOXA11 could suppress apoptosis and anoikis of gastric cancer cells. The gene discussed is HOXA11; the disease is gastric cancer.