Moreover, expression of the miR-5188-targeting protein FOXO1 was attenuated in HBX-overexpressing HCC cells and increased in HBX-suppressed HCC cells (Figure 6G), demonstrating that HBX modulates the miR-5188/FOXO1/β-catenin/c-Jun feedback loop to drive Wnt/β-catenin activation. This evidence concerns the gene FOXO1 and hepatocellular carcinoma.