The expression of Cntrl and C5, both of which are lnc-Hser neighboring genes, and C5AR1 which is a member of GPCRs family and plays an essential role in the early events leading to HCs proliferation and liver fibrosis 30, 31, was determined in either lnc-Hser over-expressed or silenced primary HCs and AML12 cells. This evidence concerns the gene CNTRL and Hepatic fibrosis.