Our group have recently demonstrated that a liver-enriched lncRNA LFAR1 promoted HSCs activation and subsequently led to liver fibrosis 22, and a nuclear-retained lncRNA SCARNA10 functioned as a novel positive regulator of TGFβ signaling in liver fibrogenesis by inhibiting the binding of PRC2 to the promoters of the genes associated with ECM and TGFβ pathway 27. Here, TGFB1 is linked to Hepatic fibrosis.