GUCY2C and Hepatic fibrosis: The reason for lnc-Hser silencing did not induce significant liver fibrosis may be due to the fact that liver fibrogenesis is a complex process involved in many key factors, and the time period for hepatic fibrogenesis of the mice was only four weeks during which the liver had significant regeneration and self-renewal capacity to counteract the injury caused by silencing lnc-Hser.