FGFR1 was also highly expressed in NSCLC and promoted tumor formation in lung cancer by interacting with SOX2, Hippo/YAP1 or Hedgehog pathway as our previously work reported 12, 13, 20, while deficiency of KLB did not influence the FGFR1 levels in cultured endothelial cells 21. This evidence concerns the gene SOX2 and lung carcinoma.