FGFR1 and neoplasm: FGFR1 was also highly expressed in NSCLC and promoted tumor formation in lung cancer by interacting with SOX2, Hippo/YAP1 or Hedgehog pathway as our previously work reported 12, 13, 20, while deficiency of KLB did not influence the FGFR1 levels in cultured endothelial cells 21.