On the contrary, in the U87MG-shSPARC tumor, FNR648-HSA was located in the vicinity of blood vessels (Figure 4D; DAPI + CD31 + FNR648-HSA, and Figure S7B; FNR648-HSA as red signals) and not in remote regions from the blood vessels (Figure 4F; DAPI + CD31 + FNR648-HSA, and Figure S7D; FNR648-HSA as red signals). This evidence concerns the gene PECAM1 and neoplasm.