DNMT1 and breast cancer: The predicted target sites interactions among LncCCAT1, miR-148a/152 and DNMT1 3'-UTR are illustrated in Figure 4G. miR-148a/152 overexpression reduced DNMT1 protein levels, while miR-148a/152 knockdown increased DNMT1 protein levels in two breast cancer cell lines, in contrast to the effect of LncCCAT1 overexpression or knockdown on DNMT1 protein (Figure S3D, Figure 4H).