Mechanistically, LncCCAT1 enhanced TCF4 levels by competitively binding to miR-204/211 and facilitated β-catenin nuclear translocation by interacting with miR-148a/152 and ANXA2, resulting in the activation of Wnt/β-catenin signaling, EMT, and LncCCAT1 transcription, thereby promoting breast cancer carcinogenesis. This evidence concerns the gene TCF4 and breast cancer.