In vivo limiting dilution assay revealed that LncCCAT1 overexpression in MCF-7 cells significantly increased tumor incidence, while miR-204/211, miR-148a/152, or sh-ANXA2 lentivirus abrogated the LncCCAT1-enhanced tumorigenicity of MCF-7 cells in vivo (Figure 7B, Figure S9A-C). The gene discussed is ANXA2; the disease is neoplasm.