Secreted frizzled-related protein 2 (Sfrp2) was recently reported to play a critical role on cardiac fibrosis after myocardial infarction (MI), partially through activating bone morphogenic protein 1 (BMP1) to initiate a feed-forward loop between TGF-β and BMP1 7-9. The gene discussed is BMP1; the disease is myocardial infarction.