In the present study, we investigated the role of Maf1 in AB- and PE-induced cardiac hypertrophy and demonstrated that Maf1 could block cardiac hypertrophy in vivo and in vitro. The data show that Maf1 ameliorates cardiac hypertrophy by inhibiting pol III transcription via direct regulation of ERK1/2. Here, MAF1 is linked to cardiac hypertrophy.