KCNQ1OT1 and cancer: While conceptually the use of DNA hypermethylation events as biomarkers might be preferred due to the desire for a gain of 'signal' specifically in cancer-containing samples, DNA hypomethylation events have also emerged as reliable biomarkers as highlighted by Moss et al. using cfDNA 25, through studies of the KCNQ1OT1 locus for imprinting disorders 41, and by several investigations of potential biomarkers for the detection of liver and other solid tumor types based on tissue 42, 43.