To assess the prognostic value of the combination of PAI-1 and α-SMA expression in pancreatic cancer, we divided the patients into 3 groups: the high expression group (staining percentages of PAI-1 ≥ the mean value of 56% and α-SMA ≥ the mean value of 55.5%; N=42), the low expression group (staining percentages of PAI-1 < 56% and α-SMA < 55.5%; N=37) , and the inconsistent group (staining percentages of PAI-1 ≥ 56% and α-SMA < 55.5% or staining percentages of PAI-1 < 56% and α-SMA ≥ 55.5%; N=12). Here, SERPINE1 is linked to familial pancreatic carcinoma.