Second, different combinations of ten genes (RTEL1, TERT, TERC, STN1, ATM, SP110, SEMA3E, TBX1, DNMT3B, CDCA7) related to the category “Combined immunodeficiencies with associated or syndromic features” were overrepresented in 11 neoplastic diseases/traits. This evidence concerns the gene SEMA3E and neoplasm.