TNF and diabetes mellitus: However, compared with that in the control group, the expression of miR-146a and NF-κB were increased, expression of TRAF6 was decreased, and expression of TNF-α, IL-6, and IL-1β were increased in the sciatic nerve of DM rats, indicating that loss of NF-κB/miR-146a in the negative feedback loop may underpin the pathogenesis of diabetic peripheral neuropathy (43).