Given the fact that: (1) the orexin system efficiently controls appetite and feeding as well as the energy balance and metabolism and (2) OXA exhibits potent neuroprotective function, for example by attenuating oxidative stress-induced cell death, another team was interested in deciphering how the dynamic orexin-microglia dialogue might interfere with brain health to induce obesity through high fat diet in saturated fatty acids (SFA) [i.e., palmitic acid (PA, C16:0)] exposure (66). Here, HCRT is linked to obesity due to melanocortin 4 receptor deficiency.