Supporting a role for endogenous orexin in neurodegenerative/inflammatory brain pathology, orexin expression was found to be elevated in lesioned CNS areas in murine controlled cortical impact (CCI) and transient common carotid artery occlusion (tCCAO), models of traumatic brain injury and cerebral ischemia, respectively (64, 65). This evidence concerns the gene HCRT and Cerebral ischemia.