MAPT and supranuclear palsy, progressive, 1: However, despite these off-target binding, studies on PSP patients showed that [18F]AV-1451 also binds to the PSP-specific subcortical areas with tau pathology, including dentate nucleus, thalamus, midbrain, pallidum and striatum (24, 25, 208, 209), which makes it a favorable tracer in studies of PSP.