MAPT and supranuclear palsy, progressive, 1: Based on epidemiological and experimental studies, exposure to herbal neurotoxins containing mitochondrial complex I [CI, NADH:ubiquinone oxidoreductase (152)] inhibitors (mainly fruits and tea made from the Annonaceae family) is a risk factor for a PSP-like parkinsonian disorder with brainstem-predominant 4R-tau inclusions in the French West Indies (153–156).