ITM2B and ADan amyloidosis: To explore whether ITM2B mutations linked to FBD (Vidal et al., 1999), FDD (Vidal et al., 1999), or FRD (Audo et al., 2014) have any noticeable effect on urate transport mediated by GLUT9 isoforms, we generated the FBD, FDD and FRD mutants of ITM2B, and then co-expressed with GLUT9a/b in oocytes.