Multivariate analysis of patients and controls, adjusted for age, sex and smoking status (pack-years), revealed that dry AMD was an independent factor associated with lower concentrations of TNF-α (β = +0.24, p = 0.0004), IL-1β (β = −0.39, p < 0.001), IL-2 (β = −0.20, p = 0.003), IL-5 (β = −0.54, p < 0.001), IL-10 (β = −0.56, p < 0.001), IL-12 (β = −0.51, p < 0.001) and higher concentration of GM-CSF (β = +0.34, p < 0.001) and IL-6 (β = +0.13, p = 0.05). Here, TNF is linked to dry age related macular degeneration.