In conclusion, we found significantly modified miRNA expression levels in peripheral blood cells (miRNA-16-5p, miRNA-17-3p, miRNA-17-5p, miRNA-23a-3p, miRNA-30b, miRNA-126-3p, miRNA-146a, miRNA-155-5p, and miRNA-191-5p) and soluble inflammatory factor concentrations in the plasma of AMD patients (IL-2, GM-CSF, IFN-γ, IL-1β, IL-5, IL-10, and IL-12), suggesting that, among others, these biologically active molecules have an important role in AMD. This evidence concerns the gene IFNG and age-related macular degeneration.