FUS and amyotrophic lateral sclerosis: Proteasomal dysfunction plays a critical role in ALS (Shahheydari et al., 2017), and we demonstrated that mutant FUS induced defects in protein homeostasis in iPSC-derived SNs (Marrone et al., 2018, 2019), leading us to speculate that proteasomal defects might contribute to the sensitivity of SNs with mutant FUS to rabies infection.