Since small amounts of aggregated RBPs such as TDP-43 and FUS also induce aggregation of soluble wild type proteins, it has been suggested that ALS-associated RBP aggregates behave like prions (Furukawa et al., 2011; Polymenidou and Cleveland, 2011; Nomura et al., 2014). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.