Previously, iPSC-derived SNs with mutant FUS were shown to be more likely to degenerate compared with isogenic WT controls as a result of disruption in the levels of multiple ALS-associated RNA-binding proteins, including hnRNPA1, hnRNPA2, EWSR1, and TAF15 (Marrone et al., 2018). This evidence concerns the gene TAF15 and amyotrophic lateral sclerosis.