Quantification of protein colocalization demonstrated that, despite lack of SG formation, G3BP1/FUS colocalization was increased in both WT FUS and FUS-P525L mutant SNs following virus infection by either HIV-1 (e.g., LL MUT, -virus vs. HIV-1, p < 0.001, 1way ANOVA, Tukey post-test for multiple comparisons), or ZIKV (e.g., ZIKV, LL WT vs. LL MUT, p < 0.01, 1way ANOVA, Tukey post-test for multiple comparisons; Figures 4C,D). This evidence concerns the gene G3BP1 and viral infectious disease.