Evidences to date have pointed that ADLD has been identified as the result of overexpression of lamina B1, and it is the first and only neurological disease related to LMNB1, located on chromosome 5q23-31 (Coffeen et al., 2000; Marklund et al., 2006; Padiath et al., 2006; Meijer et al., 2008; Brussino et al., 2010). The gene discussed is LMNB1; the disease is adult-onset autosomal dominant demyelinating leukodystrophy.