By contrast, the Italy-1 family was distinguished from others and defined as ADLD-1-TO because of variant features of the absence of the autonomic dysfunction, relative sparing of cerebellar WM, and the increased laminB1 mRNA without LMNB1 duplication (Brussino et al., 2010; Giorgio et al., 2015). Here, LMNB1 is linked to Abnormal autonomic nervous system physiology.