Activation of the RAAS in adipose tissue is associated with high blood pressure in both animal models of visceral obesity53,54 and obese hypertensive patients.55 The presence of angiotensinogen in adipose tissue may have further implications in obesity-linked hypertension, as Ang II plays a major role in the growth and differentiation of adipocytes in rodents.56 The gene discussed is AGT; the disease is obesity due to melanocortin 4 receptor deficiency.