LMNA and lipodystrophy: Mutations in LMNA are associated with lipodystrophy, hyperinsulinemia, dyslipidemia, diabetes, and hypertension.105,106Prelamin (LMNA) mRNA contains 12 exons (Figure 7) and is alternatively spliced to produce three isoforms, lamin A, progerin, and lamin C. Lamin A and C differ due to splicing of exon 10, while progerin differs from Lamin A due to alternate splicing of exon 11 (Figure 7).101 This results in progerin being 50 amino acids shorter than lamin A at the C terminal.