Since loss or inactivation of tumor suppressor PTEN is well-characterized to trigger cell senescence in mouse prostate [43, 44] and also play a crucial role in the development and advance progression of prostate cancer [45–47], we then examined the possible association between HNF4α and PTEN in prostate cancer cells with HNF4α overexpression. This evidence concerns the gene PTEN and Familial prostate cancer.