PPI peptides appeared to have some effect on the development of diabetes, as mice treated with HSA plus PPI peptides (G5, open diamonds, Fig. 6B) also had slightly improved BG trends compared to controls in Fig. 6A, however this effect was significantly improved by the addition of Tregitopes in the HSA-fusion E + PPI group (G6, closed circles, Fig. 6B). This evidence concerns the gene ALB and diabetes mellitus.