A similar association was observed between tumor pathological grade and P-Smad2 expression: more that 48% of high grade (Grade III) tumors expressed high levels of P-Smad2 while only 7.3% of low grade (Grade I + II) tumors showed high levels of P-Smad2 expression (χ2 test: P = 0.05) (Table 1/Fig. 1B). This evidence concerns the gene SMAD2 and neoplasm.