To gain further insights into the mechanisms by which IL-27R signaling influences HSC function and “stress-induced” hematopoiesis in AAA, we performed whole transcriptome RNA-sequencing analysis of FACS-sorted LT-HSCs (Lin−Sca-1+c-kit+CD150+CD48−) and HPC-1 (Lin−Sca-1+c-kit+CD150−CD48+) isolated from the BM of Apoe−/−, Apoe−/−Il27ra+/−, or Apoe−/−Il27ra−/− mice fed the WD and infused with PBS or Ang II for the last 2 weeks of the feeding. This evidence concerns the gene APOE and triple-A syndrome.