However, because of Ang II-driven increase in atherosclerosis in Apoe−/−Il27ra+/− but not in Apoe−/−Il27ra−/− mice, Apoe−/−Il27ra+/−, and Apoe−/−Il27ra−/− Ang II-infused mice develop equally high levels of atherosclerosis. The gene discussed is AGT; the disease is atherosclerosis.