CD8A and neoplasm: In addition to rMVA and rMVA-CD40L, rMVA expressing profilin (rMVA-Profilin)—a protein derived from the protozoan parasite Toxoplasma gondii that is specifically recognized by mouse CD8α+ cDCs via TLR11 and TLR1224–26—was used to immunize tumor-bearing littermates.