The demonstration of nuclear involvement in TyrRS-induced CMT could have important implications for other aaRSs associated with CMT, as all aaRSs were described to localize to the nucleus of the cell and at least two other CMT-linked aaRSs (i.e., MetRS and AlaRS) have known functions in the nucleus37,38. The gene discussed is AARS1; the disease is Charcot-Marie-Tooth disease.