The observations that there was a concurrent up-regulation of BRG1, CCNB1, and LTBP2 in high-grade human lung cancers combined with the well-established roles of CCNB1 and LTBP2 in cancer cell proliferation and migration prompted us to investigate whether BRG1 may contribute to hypoxia-induced LLC cell proliferation and migration by regulating CCNB1 and LTBP2 expression. The gene discussed is CCNB1; the disease is cancer.