Also, analysis of publicly available Cancer Genome Atlas (TCGA) Datasets, revealed that a higher expression of MKK3 is correlated to significantly poorer prognosis as compared to low MKK3 expression in CRC patients (p = 0.0487) (Fig. 1c and Supplementary Table 2), supporting the prognostic and pathobiologic relevance for MKK3 in CRC. This evidence concerns the gene MAP2K3 and colorectal carcinoma.