In this study, we demonstrated that in CRC p38delta MAPK is induced, and indeed highly phosphorylated by MKK3 as a result of 5-FU exposure, indicating that, beyond p38 MAPK alpha-mediated induction of apoptosis, also MKK3/p38delta MAPK pro-survival signaling is further triggered upon drug treatment. Here, MAP2K3 is linked to colorectal carcinoma.