Genome-wide analysis of methylation and corresponding gene expression comparing APA, normal adrenocortical tissue (including the ZG, fasciculata, and reticularis) and nonproducing adenomas demonstrated, among other differentially methylated and expressed genes, higher expression and decreased methylation of CYP11B2 in APAs52, and these results were confirmed in an independent study53. Here, CYP11B2 is linked to adenoma.