Kcnk3 (TASK-1) knockout mice show the expression of Cyp11b2 in the reticulo-fasciculata zone instead of in the ZG and develop severe hyperaldosteronism (including hypokalemia and low renin levels) remediable by glucocorticoids, representing clinical features of FH-I90. This evidence concerns the gene KCNK3 and Hypokalemia.