FOXO3 and hepatocellular carcinoma: Other studies have reported that FOXO3a could regulate doxorubicin-induced autophagy via protein transcription including DEEP, ATG4B, and LC310,29, hence further investigation is needed to clarify the in-depth mechanism by which FOXO3a directs miR-223-associated doxorubicin-induced autophagy in HCC.