The increased numbers of pMo and iMo in ABIN1[D485N] mice are, therefore, driven by the same MyD88-IRAK4-IRAK1 signaling pathway that drives lupus but, similar to the liver pathology, the increases in these monocytes are unaffected by the absence of IL-6 or an adaptive immune system. Here, MYD88 is linked to systemic lupus erythematosus.