MyD88 forms oligomeric complexes with members of the IL-1 receptor-associated kinases (IRAKs), termed the Myddosome, and lupus in ABIN1[D485N] mice is also prevented by crossing to mice in which IRAK4 or IRAK1 are replaced by kinase-inactive mutants. The gene discussed is MYD88; the disease is systemic lupus erythematosus.