BXSB/Yaa mice in which the TLR7 gene is duplicated develop an autoimmune disease similar to ABIN1[D485N] mice (Pisitkun et al, 2006; Santiago-Raber et al, 2009b) and the spontaneous development of lupus in several other lupus-prone mouse lines is attenuated by crossing to TLR7 KO mice (Christensen et al, 2006; Demaria et al, 2010; Santiago-Raber et al, 2010). Here, TLR7 is linked to autoimmune disease.