TLR7 and Autoimmunity: Flt3-derived plasmacytoid dendritic cells from ABIN1[D485N] mice overproduce IFNα and IFNβ upon stimulation with ligands that activate TLR7 or TLR9, but autoimmunity is unaffected by crossing to mice that lack the type 1 IFN-associated receptor 1 subunit (IFNAR1), which is essential for type I IFN signaling.