TLR9 and systemic lupus erythematosus: Recently, another laboratory reported that crossing ABIN1 KO mice to either TLR7 KO mice or TLR9 KO mice had little effect on autoimmunity or glomerulonephritis and that crossing to TLR7/TLR9 double KO mice was required to prevent these hallmarks of lupus (Kuriakose et al, 2019).