TNIP1 and Splenomegaly: Remarkably, increased numbers of pMo in the blood and spleen were already detectable when the ABIN1[D485N] mice were only 4 wk old, 8 wk before the onset of splenomegaly and increase in ANA (Figs 4 and S4) and 12 wk before glomerulonephritis, liver pathology, or lung inflammation became detectable (Nanda et al, 2011; Caster et al, 2013).