IGHE and glomerulonephritis: Consistent with these observations, the levels of dsDNA antibodies, as well as the total IgM, IgG, and IgE, in the serum were reduced in ABIN1[D485N] × IL-6 KO mice relative to the ABIN1[D485N] mice (Figs 1C–E), and glomerulonephritis was strongly suppressed (Figs 1F, and S1B).