Genes co-expressed with the RBMS3-WNT5A pair were significantly SSc-related across more conditions than the genes co-expressed with RBMS3 and MSI2. The patterns for the two gene pairs suggest that the RBMS3-MSI2 interaction may be more involved in autoimmunity, whereas, the RBMS3-WNT5A interaction may be more involved specifically in lung disease and SSc-specific processes. This evidence concerns the gene RBMS3 and systemic sclerosis.