S1PR5 and systemic sclerosis: Sphingosine-1-Phosphate Receptor 5 was found to modulate early fibrogenesis in a mouse model of SSc (Schmidt et al. 2017), and the selective S1P1 receptor modulator cenerimod has been shown to attenuate lung and skin fibrosis in two different mouse models of SSc (Kano et al. 2019).